Naphthoquinone hybrid as antimalarial
WitrynaIn this study, four novel naphthoquinone–thiazole hybrids bearing adamantane were synthesized byreaction of naphthoquinone–aroylthiourea derivatives with 1-adamantyl bromomethyl ketone in 75-85% yield and werecharacterized using 1H/13C NMR, FT-IR, and HRMS techniques. Various biological activities of the synthesizedcompounds, … WitrynaIn this respect, lawsone derivatives, 3-(aminomethyl)-2-hydroxy-1,4-naphthoquinones 6, or amino naphthoquinone Mannich bases have been synthesized and evaluated as anticancer, antimalarial, antiviral, antifungal, and antibacterial molecules [19,20]; amino 7, and thioether 8 NQs , as well as the NQs with aromatic amines in carbon two or …
Naphthoquinone hybrid as antimalarial
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WitrynaDeveloped hybrids of two potent antimalarial compounds followed by structure-based drug design to discover potent naphthoquinone-based molecules against malarial and methicillin-resistant ... Witryna14 sty 2024 · Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by Plasmodium falciparum (including chloroquine-resistant P. falciparum/P. vivax). Numerous quinone-derived compounds have attracted considerable attention …
Witryna19 gru 2024 · Naphthoquinone derivatives have been described as potentially promising for the development of anti-malarial leader molecules. In view of that, the focus in … Witryna5 lip 2024 · The hybrid antimalarial approach. July 2024; ... Design, synthesis and antimalarial activity of some new 2-hydroxy-1,4-naphthoquinone - 4-hydroxyanil...
WitrynaLapachol (2, Figure 1), a prenylnaphthoquinone occurring in Central and South American species of Handroanthus spp. (synon.Tabebuia, Bignoniaceae family) [] and first isolated from Tabebuia avellanedae, in 1882 by Paternó [], was used as an antiplasmodial drug during World War II, when there was a shortage of quinine, the only available … WitrynaThen, with the aim to kill multiresistant strains, we designed new hybrid antimalarial drugs with a dual mode of action, due to the presence within a single molecule of two pharmacophores that are not necessarily expected to act on the same biological …
WitrynaRolf Müller, R. Müller, 2004, Journal of Cancer Research and Clinical Oncology.
Witryna15 sty 2024 · Several semi-synthetic derivatives of natural quinones, synthetic quinones (naphtho-/benzo-quinone, anthraquinones, thiazinoquinones), and quinone-based … hugh jackman happy feetWitrynaAcequinocyl is a highly lipophilic naphthoquinone derivative. Similar compounds (2-alkyl-3-hydroxy-1,4-naphthoquinones) have been known for a considerable time to have a variety of pesticidal activities including antibacterial, acaricidal, antimalarial, fungicidal, and insecticidal actions (e.g., see Jacobsen and Pedersen, 1986). Acequinocyl ... holiday inn express downtown albanyWitryna20 paź 2015 · A novel series of 1,4-naphthoquinones (33-44) tethered by open and closed chain sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and antimalarial activities. All quinone-sulfonamide derivatives displayed a broad spectrum of cytotoxic activities against all of the tested cancer cell lines … holiday inn express downtown boise idahoWitryna7 lis 2024 · There are few research reports on the drug-likeness score for quinoline-based hybrid compounds with antimalarial activity. In hybrid compounds containing 7-chloro-4-aminoquinoline and 3-amino-1,4-naphthoquinone scaffolds reported by Kashyap et al. most of the compounds exhibited good drug-likeness scores in the … hugh jackman in blue thunder movieWitrynaThe naphthoquinone atovaquone, an analog of ubiquinone (coenzyme Q10), commonly used to treat pneumocystis pneumonia and malaria, inhibits complex III in cancer cell lines and breast cancer-stem-cells, by competitive inhibition of the active site of ubiquinone (Fiorillo et al., 2016 ). Atovaquone inhibits the ETC, decreases OxPhos, … hugh jackman halle berryWitryna1 lis 2024 · Molecular docking and molecular dynamics studies were also performed to evaluate the probable interactions between the hybrids and human ATP binding … hugh jackman human resourcesWitryna21 sie 2012 · Improving the solubility of polysubstituted 1,4-naphthoquinone derivatives was achieved by introducing nitrogen in two different positions of the naphthoquinone core, at C-5 and at C-8 of menadione through a two-step, straightforward synthesis based on the regioselective hetero-Diels-Alder reaction. … hugh jackman hollywood bowl