Lineage tracing reveals the phylodynamics
Nettet26. feb. 2024 · We applied a Cas9-based, single-cell lineage tracer to study the rates, routes, and drivers of metastasis in a lung cancer xenograft mouse model. We report deeply resolved phylogenies for tens of thousands of cancer cells traced over months of growth and dissemination. This revealed stark heterogeneity in metastatic capacity, … Nettet13. okt. 2024 · Here, we introduced an evolving lineage-tracing system with a single-cell RNA-seq readout into a mouse model of Kras;Trp53(KP)-driven lung adenocarcinoma which enabled us to track tumor evolution ...
Lineage tracing reveals the phylodynamics
Did you know?
Nettet25. jul. 2024 · In a recent issue of Cell, Yang et al. utilize evolvable cellular barcodes to investigate the evolutionary trajectories of murine lung adenocarcinoma. Reconstructing the life histories of these tumors based on cellular barcodes reveals stringent selection and phenotypic differences across subclonal lineages. NettetHere, we introduced an evolving lineage-tracing system with a single-cell RNA-seq readout into a mouse model of Kras;Trp53 (KP)-driven lung adenocarcinoma and …
Nettet13. okt. 2024 · This repository contains processed data associated with the manuscript "Lineage Recording Reveals the Phylodynamics, Plasticity, and Paths of Tumor … Nettet11. mai 2024 · 相关研究结果于2024年5月5日在线发表在Cell期刊上，论文标题为“Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution”。 …
Nettet5. mai 2024 · Here, we introduced an evolving lineage-tracing system with a single-cell RNA-seq readout into a mouse model of Kras;Trp53(KP)-driven lung adenocarcinoma … NettetAbstract. Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth, expansion to neighboring and distal tissu
Nettet5. apr. 2024 · A single-cell atlas of chromatin accessibility and gene expression reveals cell lineages and gene Expression patterns during Drosophila embryogenesis, ... Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Dian Yang, Matthew G. Jones, +20 authors J. Weissman; Biology. Cell. 2024; 29. PDF. Save.
Nettet7. feb. 2024 · HIGHLIGHTS. who: Dian Yang from the Department University of California, San Francisco, San Francisco, CA, USA have published the article: Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution, in the Journal: (JOURNAL) of May/26,/2024 what: The tractability of this model provides an appealing … cooler with a blenderNettet"Single Cell Transcriptomics Reveals Tumor Promoting Mammary Cell Subpopulation in Brca1 Mutant Breast Cancer Mouse Model" 8:35 pm - 8:40 pm: Discussion. 8:40 pm ... "Lineage Tracing Reveals the Phylodynamics, Plasticity and Paths of Tumor Evolution" 11:45 am - 11:50 am: Discussion. 11:50 am - 12:00 pm: cooler wiringNettet19. sep. 2024 · The internally controlled nature of iMAP should minimize the influence of mouse-to-mouse variability, thereby increasing precision relative to experimental methods that compare across mouse groups. Importantly, iMAP creates mosaic genetic inactivation across tissues. Such mosaics allow for the study of cell-autonomous effects, as many … family of 6 carsNettet9. aug. 2024 · Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In … cooler with a lid shockNettet21. mar. 2013 · Viral phylodynamics is defined as the study of how epidemiological, immunological, and evolutionary processes act and potentially interact to shape viral phylogenies. Since the coining of the term in 2004, research on viral phylodynamics has focused on transmission dynamics in an effort to shed light on how these dynamics … family of 6 drownsNettet5. mai 2024 · This lineage tracing approach uses CRISPR technology to embed each cell with an inheritable and evolvable DNA barcode. ... Lineage Recording Reveals the Phylodynamics, Plasticity and Paths of ... family of 6 caricatureNettet26. jan. 2024 · Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell. 2012; 148 (5): 886- ... Lineage tracing in humans enabled by mitochondrial mutations and single-cell genomics. Cell. 2024; 176 ... Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. … family of 6 drawing