2024 Klf2 activator

Klf2 activator

Author: vnag

August undefined, 2024

WebFeb 2, 2024 · Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulatory factor of preadipocyte differentiation. As a result of alternative splicing and alternative promoter usage, PPARγ gene generates multiple transcript variants encoding two protein isoforms. Krüppel-like factor 2 (KLF2) plays a negative role in preadipocyte … WebKLF2 can also promote the differentiation and function of B-cell through promoting CD62L, CXCR7, and β7-integrins expression [29]. ... In contrast, KLF7 has been shown to act as a tumor activator. Knockdown of the KLF7 gene can inhibit the expression of Discs Large MAGUK Scaffold Protein 3 (DLG3), which is implicated in the maintenance of ...

IJMS Free Full-Text Trichostatin D as a Novel KLF2 …

WebNov 30, 2024 · Interestingly, we have identified a US Food and Drug Administration–approved small molecule, suberoylanilide hydroxamic acid (SAHA, also … WebIn disease state, receptor activator of nuclear factor kappa-Β ligand (RANKL), an activator of osteoclasts, is elevated, whereas osteoclast inhibitor, osteoprotegrin (OPG) is reduced. The ratio of RANKL/OPG is modulated mainly by tumor necrosis factor (TNF) and interleukin-1 (IL-1) released from host cells, subsequently activating osteoclasts ... botanical gardens baton rouge wedding

Primary cilia mediate Klf2-dependant Notch activation in …

WebNov 3, 2024 · Trichostatin D (TSD) was identified as a novel Krüppel-like factor 2 (KLF2) activator. (A) Proton and carbon nuclear magnetic resonance spectroscopy ( 1 H-NMR and 13 C-NMR) data of TSD. WebMar 4, 2024 · Abstract. Acute lung injury (ALI) is a lethal disease with diffuse lung inflammation, in which JAK/STAT3 signaling has been well recognized for its role in initiating and amplifying inflammatory processes. However, the mechanism for the enhancement and maintenance of signal transducer and activator of transcription 3 (STAT3) activation has … WebSW1353 cells were infected with nonspecific control virus (Lv-NC) or KLF2-expressing virus (Lv-KLF2) or incubated with the pharmacological KLF2 activator simvastatin (Sim). After 24 h, cells were treated with or without GGPP (GP, an inhibitor of KLF2) for 8 h prior to 24 h treatment with 20 ng/ml IL-1β. (a) Real-time PCR was performed to ... botanical gardens bellevue washington

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα …

The zinc finger transcription factor, KLF2, protects …

WebJan 24, 2024 · recently identiﬁed molecular pathways, where KLF2 is the main activator of the eNOS. expression/activity and other genes known to regulate KLF2 expression. 2.1. KLF2-Based eNOS/NO Regulation. WebJan 24, 2024 · Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS … botanical gardens berlinWebMar 28, 2024 · Krüppel-like factor 2 (KLF2) is a potent regulator of lymphocyte differentiation, activation and migration. However, its functional role in adaptive and … haw oberthür

"WebApr 5, 2024 · This activation was mediated by klf2a,zebrafish homologue of the human Krüppel-like factor 2 gene (KLF2) which encodes a well-known hemodynamic responsive transcription factor playing a crucial regulatory role in vascular and cardiac morphogenesis in vivo(Lee et al., 2006; Goddard et al., 2024). " - Klf2 activator

Klf2 activator

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is …

WebJan 24, 2024 · DF induces LOX-1 expression via AP-1 (activator protein-1) TF, while KLF2 acts as an inhibitor to AP-1. These results suggest that KLF2 activation is a crucial factor in LOX-1 expression by shear stress, where … WebNov 18, 2024 · Given the robust microglial response seen in K2KO mice, we believe that KLF2 serves to regulate aberrant activation of hypothalamic microglia, thereby protecting against centrally derived...

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WebActivation of the endothelium by inﬂammatory cytokines is a key event in the pathogenesis of vascular disease states. Proinﬂammatory cytokines repress the expression of KLF2, a recently identiﬁed transcriptional inhibitor of the cytokine-mediated activation of endothelial cells. In this study the molecular basis for the WebMar 28, 2024 · KLF2 is a key regulator of activation, differentiation, and migration processes in numerous cell types, including endothelial cells function and vascular homeostasis . KLF2 plays a significant role in COVID-19 as SARS-CoV-2 significantly down-regulates KLF2 expression: COVID-19 patients have elevated serum levels of TNF-α and IL-1 and ...

WebApr 30, 2024 · KLF2 is known to be upregulated in response to shear stress and to induce activation of numerous downstream signaling pathways that exert protective effects against atherosclerosis [28, 29]. However, expression of KLF2 is flow-dependent, and OSS had been shown to induce transient upregulation of KLF2 followed by prolonged suppression [ 30 ]. WebNov 3, 2024 · KLF2 is an atherosclerotic protective transcription factor that regulates endothelial cell inflammation, thrombosis, and angiogenesis [ 4, 13, 14, 15, 16 ]. Therefore, discovery of new small molecule compounds that are KLF2 activators may provide new therapeutic strategies for atherosclerosis.

WebMar 28, 2024 · KLF2 is predominantly expressed in early IgA + plasmablasts in mesenteric lymph nodes To analyze the abundance of KLF2 during PC differentiation, we performed flow cytometric analyses of PB/PC... WebApr 1, 2024 · TL;DR: Results demonstrate that autophagy is an important mechanism related to Klfs in smooth muscle cells during AAA formation, and Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagic genes in smooth Muscle cells following elastase treatment. Abstract: Abdominal aortic aneurysms …

WebApr 13, 2024 · With regard to the positive role of mROS, but not of H 2 0 2, in certain inflammatory processes and with regard to ROS-mediated ERK5 activation, the Coon study about the activation of the MEK5/ERK5/KLF2 pathway by fluid shear stress-induced mtROS production has been added in the revised manuscript as suggested by the Reviewer …

botanical gardens bhamWebNov 25, 2010 · KLF2 was initially found in T cells to maintain the quiescent state of single-positive CD4 + or CD8 + T cells. 22, 25 KLF2 also inhibits Jurkat T-cell growth by inhibiting DNA synthesis. 29 Mechanistically, both activation and inhibitory domains of KLF2 are required to suppress Jurkat T-cell proliferation. ha wo che tsuenWebJan 10, 2024 · Entrez Gene Summary for KLRF2 Gene. Enables protein homodimerization activity. Predicted to be involved in natural killer cell degranulation and positive regulation … botanical gardens bilpinWebJul 12, 2024 · Previous studies have shown that KLF2 is a negative regulator of endothelial activation, dysfunction, and thrombosis. 37,38,39 KLF2 expression was downregulated by … hawo beatsWebKLF2 orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. botanical gardens big island hiWebOct 13, 2024 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. … botanical gardens bham alWebKLF2orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This … hawo can to enternetexplorer active