Webb3 mars 1998 · The inhibitory effects we have observed for PNAs targeted to rRNA are consistent with reports of in vitro translation inhibition by modified and unmodified antiribosomal oligonucleotides (3–7). Also, structural probing experiments have revealed regions of the ribosome that are accessible for hybridization ( 6 ). Webb27 okt. 1998 · The question arises whether polyamides can permeate human cells and specifically regulate genes transcribed by pol II (RNA polymerase II). As a first case study, we examined the ability of polyamides to inhibit HIV type 1 (HIV-1) transcription in cell-free assays and viral replication in human lymphocytes. The HIV-1 enhancer/promoter …

Inhibition of RNA polymerase II transcription in human cells by

Webb5 mars 2003 · Treatment. Concentration, μM. Muscle formation*. Methylation, % (95% CI)†. Avg plating efficiency, % (95% CI)‡. *Mouse embryonic fibroblast C3H 10T1/2 C18 (10T1/2) cells were treated with the indicated cytidine and deoxycytidine analogs for 24 hours and scored for the presence of myotubes 9–10 days later as + to +++, with + … Webb15 feb. 2000 · To demonstrate that reduction in pH i was caused by specific inhibition of the NHE1 by HMA, KG-1a cells were subjected to intracellular acidosis by treatment with 20 mmol/L NH 4 Cl for up to 5 hours. Results are shown in Table 1 and demonstrate that in contrast to cells incubated in the absence of HN 4 Cl, there is a gradual but expected … c.s. herediano

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WebbApplication: SU 3327 is a selective inhibitor of JNK shown to inhibit the protein-protein interaction between JNK and JIP CAS Number: 40045-50-9 Purity: ≥95% Molecular … WebbC527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro. However, the IC 50 of C527 for these DUB enzymes was higher in comparison … Webbwww.ncbi.nlm.nih.gov eager curious